While some advocacy groups and doctors argue that, over time, lipstick wearers might absorb levels of lead that could result in behavioral issues, the Food and Drug Administration has said that the trace amounts of lead in makeup are too small to cause harm.
In cluster 6, genes were downregulated at low absorbed doses and upregulated at high absorbed dose levels even though the shift from down- to upregulation occurred at a lower absorbed dose level for 211At compared with 131I.
In the spleen, the reverse relationship could be seen where Cfd showed a nine-fold decrease in expression at the lowest absorbed dose level followed by an increase to about a two-fold decrease at the two higher absorbed dose levels.
A (very) low absorbed dose level is not expected to result in up-regulation of the DNA damage recognition and repair machinery on the transcriptional level.
It is found that moisture-induced tensile stress on the fiber is substantial when absorbed moisture level in the polymer matrix is high.
Such a relation was also identified 24 h after 131I administration; however, at a lower absorbed dose level (0.85 and 8.5 Gy).
A microsphere concentration causing an absorbed dose level that low is rare for resin spheres and was not investigated in our samples.
These non-thyroidal tissues, that are exposed at a much lower absorbed dose level compared with thyroid, shared regulation of 19/27 and 6/27 recurring genes after 211At and 131I exposure, respectively.
However, chromatin organization was strongly affected after 1 h in kidney medulla and also showed response to at least one absorbed dose level after 24 h in all of the investigated tissues in the previous study [20].
Interestingly, however, in the present study, we demonstrate that genes, e.g., associated with ILK signalling were generally upregulated at higher absorbed dose levels and downregulated at lower absorbed dose levels, suggesting different involvement of this signalling pathway at different absorbed dose levels.
