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There was a realistic estimate of absolute healing rate with EXOGEN from a large registry study [ 14], supported by evidence from smaller case series.
The EAC agreed, broadly, with the absolute healing rates the sponsor quoted for EXOGEN, (90 % [87 92 %] and 84 % [80 89 %] for delayed and non-union, respectively [ 14]).
After discussion with wound care clinical experts that included a plastic surgeon, a nurse practitioner, enterostomal therapists, a chiropodist, and advance practice nurses, we estimated the minimal clinically important difference to be a 40% improvement in the normal rate of healing (8.65% per week), which corresponded to an absolute healing rate of 12.11% per week.
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We expected the absolute rate of healing in the clinic group at 3-months to be 40%, a figure falling between the extremes (20%–89%) for 3-month healing rates in previously reported leg ulcer clinic studies [ 11, 13].
For those thirsting for waters of hopeful quenching, the Gospel is where the redemptive, refreshing and re-born rivers of life, total healing and absolute truth is found.
In absolute values, the excellent healing capability of autograft was apparent, and the BV/TV was not significantly differerent from that of the adjacent calvarial bone, which was used as a reference.
In the presence of fluid collections in the pleural cavity or mediastinum, adequate resolution of these fluid collections is an absolute prerequisite for complete healing of an esophageal rupture or anastomotic leak.
The most relevant measure of clinical importance will be one derived from a cohort study, that is where the effect of bisphosphonate use can be represented in terms of a relative and/or absolute risk of delayed dental healing.
I explained to him that without absolute faith there would be no healing.
Secondary outcomes were proportion of patients healed by 12 months, percentage and absolute change in ulcer size, proportion of time participants were ulcer-free, health related quality of life, and adverse events.
This preserves the local blood supply and results in less surgical damage to soft tissues, replacing absolute stability by relative stability to achieve bone healing by stimulating bone formation.
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