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Absence of a split signal in G59 suggests absence of translocation, although we cannot exclude a breakpoint outside the investigated region.
Recently, it has been suggested that the over-expression of MYC in the absence of translocation might be due to miRNA deregulation [10].
It might be argued that the virus may be able to modulate hsa-miR-9* expression in the absence of translocation, being now clear the existence of a delicate and complex interplay between viruses and cellular miRNAs [29] [32].
E2F1 over-expression observed in MYC translocation-negative BL cases could be responsible for c-Myc over-expression, and to sustain it at high levels in the absence of translocation.
In particular, E2F1 over-expression observed in BL cases lacking the typical translocation may represent itself an appealing possible mechanism able to determine c-Myc over-expression and sustain it at high levels in the absence of translocation, due to the existence of a feedback loop responsible for controlling the reciprocal expression of these transcription factors.
The risk of outbreeding depression therefore must be weighed against the immediate risk of population decline/extinction in the absence of translocation.
Similar(49)
In particular, it is down-regulated only in MYC translocation-negative BL cases, giving evidence that its deregulation could influence c-Myc expression in the absence of genomic translocation.
(a) Lower left panel: shows absence of nuclear translocation of NF-κB-p65 in OECs maintained in their normal culture medium alone.
These results indicate that RecBCD can unwind duplex DNA processively in the absence of ssDNA translocation by the canonical motors and that the nuclease domain regulates the helicase activity of RecBCD.
RESULTS: The viability of RPE after a prolonged sublethal injury dose of HQ was determined by multiple assays and confirmed by the absence of AIF translocation or DNA laddering.
This absence of background translocation of βγ9 induced by endogenous αq allowed us to examine whether the tagged αq-CFP was functional.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com