Hence, proteins from the cytotoxic exocytic pathway may have additional functions in other immune cell types (such as inflammatory cells), the absence of which modulates the pathogenesis of HLH.
Further weakening arguments for causal associations is the absence of well-defined plausible models of pathogenesis.
The absence of CTB1 induction during these stages of pathogenesis suggests that other virulence/pathogenicity factors may play a greater role in the initial colonization of leaf tissue.
Besides, in the absence of significant insights into disease pathogenesis, comprehensive bioinformatics technologies may help us to get deep understanding of such complex and life-threatening illness thus may provide novel therapeutic targets.
In the absence of greater understanding of AD pathogenesis, treatment strategies do not provide a cure but only treat symptoms or reduce the rate of onset [3], [4].
The mutants with deleted copy of the gene showed absence of cholesterol glycosylation and impaired pathogenesis.
In the absence of significant insights into disease pathogenesis, comprehensive gene array analysis of tissues derived from animal models of disease is also often helpful in identifying candidate genes.
The absence of specific treatment prompts research aiming at further understanding of pathogenesis and the development of effective antiviral therapy, which in turn requires advanced experimental models.
Longitudinal data are needed to describe the patterns of sickness absence in specific diagnostic groups and to provide a better understanding of pathogenesis.
