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The difference could explain the absence of grade 3 4 neurotoxicity in our patients, pretreated also by taxanes.
Paraesthesia was scored as the presence or absence of grade I sensory neuropathy according to Common Toxicity Criteria 2.0.
In the absence of grade IV haematological toxicity and normal recovery of haematopoiesis, paclitaxel dose was escalated.
In the absence of grade 3 4 toxicity at this level, further patients received treatment at the 1·0 mg dose level.
The relative absence of grade 3/4 adverse events other than neutropenia and hand foot syndrome seen in this trial was remarkable.
Initial cohorts consisted of one patient with dose doublings between cohorts in the absence of grade ⩾2 toxicity according to the National Cancer Institute Common Toxicity Criteria version 3.0 during the first cycle (http://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/ctcaev3.pdf).
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But by creating less stress over failure, the report found, pupils were encouraged to take risks and participate in class, and often became more confident.Curiously, it was parents rather than pupils who most resisted the absence of grades.
Absence of grades would be another element of the appeal of regular volunteerism to young people: a weekly break from the tyranny of competition and evaluation that goes with nearly everything else about school.
Further, the absence of grade-2 alopecia in this study compared favourably to other regimens.
However, as noted previously, the absence of grades 3 and 4 ALT levels probably reduces the discriminating ability of the analysis.
The reasons for the absence of grading were the absence of pre-hospital assessment by a physician (n = 453 patients) or the non-use of the grading scale by the pre-hospital emergency physician (n = 403 patients).
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