Sentence examples for absence of efficacious from inspiring English sources

For example, after the initial training in theoretical considerations of RNA secondary structure and function, the students concluded primary literature searches on the role of RNA secondary structure in viral replication and identified the YF virus as a pathogen of interest based on the biomedical needs such as the absence of efficacious vaccines.

Although sorafenib was not effective as a single agent in advanced melanoma (Eisen et al, 2006), it was thought worthwhile to explore the utility of sorafenib in combination with chemotherapeutic agents in the treatment of patients with advanced disease, especially given the absence of efficacious treatment options.

Highly pathogenic viruses are endemic in developing countries where their impact on public health is especially important in light of the absence of efficacious treatments and vaccines 1. Occasionally, they can be brought into the developed world by travellers and could be misused for bioterrorism.

Armed with so little information about intrinsic vulnerability, the physician not only is unable to predict whether a patient will develop TD but, in the absence of efficacious treatments, also can expect that many of those for whom haloperidol is prescribed will be left with a permanently disfiguring condition.

Dengue incidence continues to increase globally and, in the absence of an efficacious vaccine, prevention strategies are limited to vector control.

2 The study does not evaluate interventions for stomach cancer because of the absence of known efficacious interventions.

Most of the centres were located in Eastern Europe, Asia, South America and Africa and likely were not yet skilled in or accustomed in the use of TKIs and possibly were forced to enter patients into clinical studies in the absence of other efficacious treatment options, mainly for economic reasons (Srinivas, 2013).

In the absence of EBOV-specific treatments, efficacious disinfectant and antiseptic products are useful to help prevent the spread of infection [ 6].

This reasoning is logical if it is assumed that the GR EPSPS enzyme functions equivalently to the wild-type EPSPS enzyme in the absence of herbicide, and is equally efficacious in supporting disease-resistance mechanisms when exposed to herbicide.

While the orange maize was expected to be efficacious, the absence of VAD and high liver stores were unexpected findings given 2009 VAD estimates of 56.4% with SR <0.7 μmol/L (unadjusted for infection) or 22% with modified relative dose-response tests >0.06 in younger Zambian children aged 2 5 y (6).

Both the "severity" of sentencing and the "certainty" (or lack of it) of getting caught and convicted have an effect on crime and imprisonment rates; one cannot be efficacious in the absence of the other.