A total of 176 lesions and 331 breasts were investigated (one breast for one patient was eliminated for absence of cytological characterization in the work-up).
Proteins shown to form amyloid-like fibrils only in vitro in the absence of a characterization of their amyloid morphology in vivo have been excluded from the analysis (these include α-synuclein, superoxide dismutase, many poly-Q containing proteins).
In the absence of further characterization of these structures, this remains an open question.
In the absence of structural characterization, our understanding of the mechanisms of membrane fusion is likely to remain nebulous.
We agree that there is some opinion in determining what is an error in the absence of experimental characterization.
Unfortunately, there is limited information available to determine the exact mechanism of conduction, stemming from an absence of structural characterization of M2 at low pH, particularly when reconstituted in lipids.
In the absence of functional characterization and expression studies for genes in each of the subfamilies, it is premature to speculate about the functional significance of these relative expression differences.
However, in the absence of an appropriate characterization of fundamental climate space, there may be no objective basis for weighting competing models to be averaged by their relative merits.
As isolate redundancy within each ST cannot be exclude in absence of complementary genotypic characterization, this analysis was performed using only one sample from each ST (non redundant STs).
