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This may be because single or later time point sampling would miss the abrupt induction and subsequent restitution of miR-34a levels we observed here.
We observed an abrogation or a reduction in transcript levels of genes encoding CEAPs during the biotrophic phase and an abrupt induction in the necrotrophic phase.
A stress response readiness may be indicated in this study by the abrupt induction of both HSP72 mRNA and intracellular HSP72 in healthy and critically ill individuals' PBMCs exposed to near-fatal HS.
Additionally, abrupt induction of respiration in highly proliferative cells (i.e. by shifting exponentially growing yeast cells on respiratory media) results in ROS-mediated apoptosis that can be avoided by addition of glutathione [ 9].
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It is unclear whether these assumptions apply to the trial, and more widely to clinical practice, since loss of consciousness is an abrupt phenomenon during induction of anaesthesia.
Tufts form during rapid vessel growth by abrupt growth factor induction in avascular regions upon return to normoxia, where vessels had previously regressed during hyperoxia.
A 35 nl injection of locust saline containing a 15-fold higher [K+] (150 mM compared to 10 mM) was sufficient to bring [K+]o to threshold for induction of an abrupt surge (Figures 2B and S1).
At high induction of glnA, the abrupt stop is restored (Additional file 1: Figure S2).
We could expect abrupt fluctuations in the rainbow trout brain, since transient induction and up-regulation of gene expression was observed in response to cold in the brain of channel catfish [ 4].
The present study utilized a case-crossover design which is most suitable for studying relations with the following characteristics: 1) the individual exposure varies within short time intervals; 2) the disease has abrupt onset and short latency for detection; and 3) the induction period is short [ 17].
This can allow us to qualitatively study the abrupt transition from consciousness to unconsciousness as well as the biphasic response during induction of anesthesia.
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