But the abrupt arrests of many of them threatened to weaken their challenge.
"Abrupt" arrests interrupt ongoing active behavior and appear analogous to cataplexy, while "gradual" arrests begin from quiet waking and are more like sleep attacks.
Both types of arrests were observed in ligand KO mice while abrupt arrests were rare in OX2R mice suggesting that residual signaling through OX1Rs may suppress them.
While we could not systematically delineate gradual arrests using our top-mounted cameras, we observed unambiguous abrupt arrests (see supplemental videos) in DKO mice supporting a role for OX1Rs in suppressing these events.
Going forward, it will be important to measure EEG and EMG in conjunction with video to delineate cataplexy from sleep attacks, especially since only about 80% of abrupt arrests in ligand KO mice initiate with REM-like EEGs [11].
If polymerization rate is independent of lateral compression, as it is in our theoretical model, an abrupt arrest of growth is expected.
Contact initiation was mediated either by OT-I T cells rolling with reduced velocity along the vascular wall or to a lesser degree by capture, i.e. an abrupt arrest of the CD8+ T cells on the vascular wall.
Rather than an abrupt stop.
His enthusiasm came to an abrupt halt.
