The phrase "abrogation on" is not correct and does not convey a clear meaning in written English.
It is typically used in legal or formal contexts to refer to the act of formally repealing or canceling a law, agreement, or policy, but it should be followed by a specific subject rather than "on."
Example: "The abrogation of the treaty was announced last week."
Alternatives: "repeal of" or "cancellation of".
Intriguingly, even though Tubb3, Scn2a and L1cam are all Rest target genes, their expression were not de-repressed in REST-null ES cells during early ES cell differentiation (Fig. 2F 2H), a view consistent with the absence of any effect of acute Rest abrogation on expression of these genes in ES cells (unpublished observations).
Hoxa1 mouse mutants show defects in neural tube closure (Lufkin et al., 1991); however, no effect of Hox gene abrogation on neural tube morphogenesis in zebrafish has been described.
We examined the impact of TRF2 abrogation on epidermal stem cell functionality by studying the expression of p63, a marker of proliferating cells of the basal skin layer in stratified epithelia, and Sox9, a stem cell gene that establishes epidermal stem cell compartments in mice during embryonic and early postnatal development (Vidal et al., 2005; Nowak et al., 2008).
To study the impact of BRCA1 or CtIP abrogation on telomeric fusions, we performed chromosome orientation fluorescence in situ hybridization (CO-FISH) on metaphase chromosomes isolated from Brca1 F/− MEFs treated with TRF2 shRNA, either alone or in combination with Cre recombinase, CtIP, MRE11 or NBS1 shRNAs (Fig 2A).
To explore the impact of Dido3 abrogation on ES cell differentiation, we used the hanging drop method to aggregate ES cells into embryonic bodies (EBs) and induced their further differentiation by propagation in gelatinized cell culture dishes in the absence of leukemia inhibitory factor (LIF).
Because the proportion of unresponsive cells remained relatively stable (∼31 46%) across different days following tamoxifen administration, and because elimination of RGS proteins result in complete abrogation of ON-BC responses to flashes (Cao et al., 2012), these cells were excluded from the analysis.
In this study, we examined the stimulatory effects of CCL25 on FLS and monocytes and effects of the abrogation of CCR9 on a murine model of RA.
These effects in A549 TP53 knockdown cells were mostly based on abrogation of TP53-mediated transcription at low concentration of SAG.
Colon crypt stem cells illustrate dependence of oncogenesis on abrogation of asymmetric division.
The above data prompted us to investigate the effect of the abrogation of CCR9 on murine CIA.
This may be a reflection of the fact that PCa metastasis is not as dependant on abrogation of cell proliferation control as compared with other factors such as loss of cell cell/cell extracellular matrix adhesion, increased cell motility, basement membrane penetration, angioneogenesis, and immune escape through impaired expression of surface tumour antigens (Hrouda and Kirby, 1998).
