Sentence examples for abrogation of interaction from inspiring English sources

Similar conclusions could be deduced by the abrogation of interaction in the absence of Triton X-100, which is required to stabilize the hydrophobic permease domain (Fig. 6, lane 5).

Mutation of the C-terminal resolving cysteine residue of CXXC motifs does not lead to abrogation of interaction, but rather in potential trapping of the substrate, more pronounced with cysteine to alanine mutations than with cysteine to serine mutation (Lee et al, 2013).

Methylation of arginine side chains may either enhance interactions by increasing hydrophobicity or act as a hydrogen donor (for review see Dacwag et al, 2009; Lee and Stallcup, 2009), although more often abrogation of interactions between proteins has been observed.

Alternatively, binding site modification can also result in partial inhibition of an interaction (64), or even complete abrogation of an interaction (65).

We performed in silico mutational analysis in order to observe the effect of the mutations on the A2M - APP interaction, and found a possible association between abrogation of this interaction and cancer.

Since the MAD2B protein almost entirely consists of the HORMA domain [21], and any deletion which affects this domain results in abrogation of the interaction, it is likely that the whole domain is required for the interaction between MAD2B and RAN.

Mutations in the PHD3-binding site or deletions in the beta2-beta3 loop lead to a significantly reduced affinity or abrogation of the interaction.

Abrogation of the interaction between p53 and TCTP-like protein can retrieve p53 tumor-inducing activity.

Abrogation of the interaction between p53 and TCTP-like protein can retrieve p53 tumor-inhibiting activity.

Collectively, our results provide strong evidence that abrogation of the interaction between Rad51 and the C-terminal region of GgBrca2 does not detectably impair HR.

In this study, we report that an Id-like protein, HHM, is a synexpression group-restricted regulator of Smad signalling, which exerts an effect through abrogation of physical interaction between Smad2/3 and certain bHLH transcription factors, including Olig1.