White et al. [ 20] reported that the LFN, an inhibitor of DHODH, led to an almost complete abrogation of neural crest development in zebrafish and to a reduction in the self-renewal of mammalian neural crest stem cells.
White et al. [ 32] reported that LFN, an inhibitor of DHODH, led to an almost complete abrogation of neural crest development in zebrafish and to a reduction in the self-renewal of mammalian neural crest stem cells.
A critical safety requirement for GAPs in order to qualify as vaccine candidate is the total absence of blood infections during immunization and therefore the complete abrogation of liver-stage development.
Although animal modes do not represent with fidelity human disease, they have provided significant insights into the abrogation of self tolerance, the development of autoimmunity, and related organ damage.
Previously, Tokita et al. [ 53] examined patterns of gene expression in the developing lower jaw of Pelodiscus sinensis and reported impairment of Shh signaling in the oral epithelium along with early-stage arrest of odontoblast development by abrogation of Msx2 expression in dental mesenchyme.
Although SAC disruption is generally associated with embryonic lethality, we provide evidence that abrogation of Dido3 expression disrupts early embryonic development through mechanisms different from those implicated in chromosome segregation.
We suggest that miR-24-mediated repression of ARF, a crucial signal transducer that bridges loss of pRB to p53-tumor surveillance, may also compromise the proper response to RB1 inactivation, alleviating the requirement for genetic abrogation of the p53-pathway during retinoblastoma development.
Abrogation of Hedgehog signaling at the developing midline disrupts the specification of the stomodeum, and the condensation of cells fated to become the pterygoid, suggesting that the stomodeum may be a critical signaling center for pterygoid development.
Pretreatment of ShhMSCs with these inhibitors abrogated PKM with concurrent abrogation of iNOS and netrin-1.
Concern was expressed about the abrogation of the anti-ballistic missile treaty and the development of missile defence systems - this refers primarily to the US national missile defence programme, popularly known as star wars.
