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We previously reported that serum opsonization abrogates the effect of cholesterol depletion on the entry of attenuated promastigote into macrophages [9].
A mutagenesis and biochemical study performed on E.coli Ffh revealed a subset of mutations that abrogates the effect of the SRP RNA and results in targeting defects in vivo [31].
The finding that DKK1 abrogates the effect of N-cadherin neutralizing antibody on ERK and PI3K signalling and cell growth confirm that Wnt signalling is implicated in the altered ERK and PI3K signalling induced by N-cadherin-LRP5 interaction in these cells.
Western blot analyses show that pretreatment with z-LEHD-fmk significantly abrogates the effect of etoposide on wtCD26 Jurkat transfectants.
Noteworthy, we provided evidence that exposure of monocytes to nuclear receptors agonists abrogates the effect of p17 [ 9].
Indeed, overexpression of the IGF-I receptor abrogates the effect of Herceptin against HER2-overexpressing SKBR-3 cells.
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Cysteine abrogates the effects of radiation by scavenging free radicals.
Another hypothesis is that persistent activation of downstream pathways abrogates the effects of the agents.
Our group has shown that inhibition of JNK activity completely abrogates the effects of chemotherapeutic drugs.
Inhibition of ATM and NF-kappaB activation abrogates the effects of VEGF on ABCG2 and anti-apoptotic protein up-regulation.
Finally, expression of a drug-resistant mutant of SIK2 in macrophages abrogates the effects of bosutinib and dasatinib on IL-10 production.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com