The phrase "abrogates the effect" is correct and usable in written English.
It can be used in legal or formal contexts to indicate that something nullifies or cancels the impact of a previous action or agreement.
Example: "The new legislation abrogates the effect of the previous law, rendering it obsolete."
Alternatives: "nullifies the effect" or "cancels the effect."
We previously reported that serum opsonization abrogates the effect of cholesterol depletion on the entry of attenuated promastigote into macrophages [9].
Clinically, that condition not only abrogates the effect of the rHuEPO, but may also neutralize endogenous EPO, leading to severe EH and transfusion-dependent anemia.
Activated caspase 3 abrogates the effect of substrates that protect cellular integrity, such as the DNA-repair enzyme PARP (Nicholson, 1999; Kraus and Lis, 2003).
Anti-TNF treatment largely abrogates the effect of mast cell reconstitution, whereas injection of TNF concurrent with infection substantially mimics the benefits of reconstitution in mast-cell-deficient mice.
Moreover, inhibition of ATM-NF-kappaB activities abrogates the effect of IL-6 on ABCG2 and anti-apoptotic protein expression (Fig. 4), indicating that IL-6 and the ATM-NF-kappaB pathway are potential therapeutic targets in inflammation-associated lung cancer chemotherapeutic resistance.
Cysteine abrogates the effects of radiation by scavenging free radicals.
Another hypothesis is that persistent activation of downstream pathways abrogates the effects of the agents.
Our group has shown that inhibition of JNK activity completely abrogates the effects of chemotherapeutic drugs.
Inhibition of ATM and NF-kappaB activation abrogates the effects of VEGF on ABCG2 and anti-apoptotic protein up-regulation.
Figure 5D shows that PRKCD silencing abrogates the effects of anti miR-26a on cyclin E anti miR-26a expression, in keeping with the results obtained with rottlerin.
Finally, expression of a drug-resistant mutant of SIK2 in macrophages abrogates the effects of bosutinib and dasatinib on IL-10 production.
