Sentence examples similar to abrogated I from inspiring English sources

Deletion of Apaf1 abrogated I-BET762 ability to induce apoptosis at 48 h.

Furthermore, the same mutations, and those within the αG helix of ROCK-I, abrogated ROCK-I-catalysed RhoE phosphorylation in vivo.

Interestingly, simultaneous inhibition of both IGF-IR and EGFR/Her-2 by NVP-AEW541 and lapatinib completely abrogated IGF-I-, EGF-, and IGF-I + EGF-stimulated phosphorylation of Akt, Erk1/2, IRS-1 (Y612) and IRS-1 (Y896), confirming at the molecular level the strong synergy observed in cytotoxicity experiments.

The protective effect of IGF-I involved blockade of the activation of FOXO 3, a transcription factor involved in brain responses to oxidative stress, by H 2O 2. Inhibition of FOXO 3 by IGF-I was mediated by Akt; i.e.: an Akt-insensitive mutant of FOXO (M-FOXO3) abrogated IGF-I effects while wild type FOXO3 did not interfere with its protective actions.

SAP treatment abrogated RIG-I binding (data not shown), thus confirming the dependency of the interaction on the 5'-terminal triphosphate group.

Beyond PC depletion, data from preclinical models had suggested that proteasome inhibition abrogated type-I IFN activity.

Heparin treatment abrogated topo I enzyme activity in Hep3B cells, but not in HepG2 cells, where the basal activity was higher.

These results demonstrated that the silencing of target genes abrogate the i-Extract mediated cell killing by protecting the cells from DNA damage, cell cycle arrest and apoptosis.

Similarly hepatitis A virus (HAV), a picornavirus, employs a cysteine protease 3ABC to abrogate IFN-I production by targeting MAVS [17].

I agree to renegotiate the old antimissile treaty, which Bush would otherwise abrogate, so I lose nothing.

In the complex of the Fc with the aglycosylated sFcγRIII, the Fc glycans are not directly associated with sFcγRIII except the primary GlcNAc of one oligosaccharide although removal of the Fc glycans abrogates sFcγRIII binding.