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This difference in toxicity between the two treatment groups may abrogate the effect MTHFR on toxicity among irinotecan-treated patients.
Further, treatment with NAC could abrogate the effect of oxidative DNA damage on MSCs, confirming that irradiation-induced DNA damage is mediated by ROS generation.
The greater response of MBV to insulin in fit individuals seen here suggests that fitness may abrogate the effect of FFAs to inhibit vascular nitric oxide production.
By using this specific inhibitor of TGF-β pathway, we were able to abrogate the effect of TGF-β in inducing CD133 expression (as well as the morphological changes) in both cell lines.
Nevertheless, the inherent ability of stem cells to respond by entering active cell cycle or even the high intrinsic radioresistance of such cells may abrogate the effect of acceleration regardless the extent of their presence in the tumour.
Lack of IL-13 did not abrogate the effect of absence of IL-4Rα-mediated signalling in DKO animals, thereby refuting the hypothesis that increased tumour initiation in IL-4Rα −/− mice is dependent on IL-13 signalling.
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While IL-6 monoclonal antibodies (Mabs) have been used to abrogate the effects of IL-6, they are only partially effective (Klein et al, 1991).
We performed Smad3 gene silencing in an attempt to abrogate the effects of radiation.
Thus, our data indicate that combined treatment with temozolomide does not abrogate the effects of sunitinib.
PKC activation can abrogate the effects of NSAIDs by decreasing c- myc expression.
The effects of 4-PBA alone in the myeloma cell lines were less notable; however, 4-PBA did abrogate the effects of lovastatin.
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