Sentence examples for abrogate function from inspiring English sources
The fact that cysteine substitution at N1392 does not abrogate function raises the question of whether it might be anionic.
The results suggest that short oligonucleotides may induce refolding of an RNA into an alternate conformation that could abrogate function.
Some cost models are focused on the erroneous "product" and propose that errors are deleterious because they abrogate function or because the mistranslated product elicits dominant negative effects downstream of translation (Drummond and Wilke 2009).
Consistent with an enzymatic activity, mutations in predicted catalytic residues of HvyA abrogate function and we were able to demonstrate limited promiscuity among HvyA, NGR_c12490, and SMc00998 in vivo, at least under conditions of over-expression.
The D10A mutation abrogates function of the RuvCI nuclease domain, generating a Cas9 capable of only nicking the DNA strand complementary to the sgRNA.
Because farnesylation of Ras is required for its transforming and proliferative activity, the farnesyl protein transferase inhibitors were designed as anticancer agents to abrogate Ras function.
Mutations generally abrogate gene function, indicating that the maize allele acts by suppressing lateral shoot development, converting grassy teosinte into slim, single-stalked modern corn and male into female reproductive structures ( 7).
A previous study showed that Akt phosphorylates Thr387 at C-terminal region of MST1 to abrogate MST1 function [41].
Indeed this has been reported in differentiating male ES cells with this Tsix-stop mutation and other mutations that abrogate Tsix function [36] [39].
The germ line arrest morphology resulting from PRDM9 knockout and from incompatible PRDM9 alleles are identical, suggesting that the incompatible alleles abrogate PRDM9 function [1], [4].
This strongly suggests that other axopathic and cytotoxic effector mechanisms present in the leukocytes collected from 90 dpi perforin-deficient donors are unable to damage demyelinated axons and abrogate motor function in our model.
