The phrase "about large changes in" is correct and usable in written English.
It can be used when discussing significant alterations or transformations in a particular context, such as economics, technology, or personal circumstances.
Example: "The report focuses on large changes in the market dynamics over the past decade."
Alternatives: "regarding significant shifts in" or "concerning major alterations in".
We also show that changes in freshwater forcing may induce large changes in sea-ice thickness, explaining about one half of the total change due to the combination of atmospheric and freshwater changes.
Clearly, the large changes in residential patterns make an important difference when we are thinking about black-white wage inequality.
Analysis of radical (large changes in the physico-chemical properties) and conservative (small changes) amino acid fixations yields useful information about modes of protein evolution.
Change in gene function might not necessarily require large changes in evolutionary rate or amino acid sequence however, with more subtle changes in sequence or regulation also able to bring about functional change.
In this particular case, relatively large changes in survival probabilities (42% to 21%) corresponded to small changes when transformed to log odds (i.e., change between food levels of about 1.6 for both saline and freshwater populations).
This brought about a large change in the dynamics of the rare-earth markets.
The artist tells The Creators Project about a large change in her artistic career: discovering acrylagouache paint.
For this reason, current social states can be far more fragile than is generally thought--as small shocks to publicly endorsed norms and roles decrease the cost of displaying deviant norms, and rapidly bring about large-scale changes in publicly displayed judgment and desires.
Ultimately, to bring about large-scale changes in practice, information on performance at all levels will need to be made routinely available a process that will require substantial changes in health information systems, including automated entry of essential data for clinical decision-making [ 24].
