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Deletion of CupB4 gene abolished the surface location of CupB1 and CupB5.
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Importantly, both genetic ablation of eIF2 phosphorylation and treatment with ISRIB but not the inactive analog ISRIB-A18 abolished the reduction in surface AMPARs and blocked mGluR-LTD (Di Prisco et al., 2014).
Second, this effective downregulation of activity was mediated by slow-acting GABAB receptors (since GABAB-receptor antagonist CGP52432 to the cortical surface abolished the inhibition; Fig. 1C), and not via the faster and stronger action of GABAA receptors.
Rp-cAMPS abolished the effect of L-SPD on pS845 (P=0.001), surface expression of GluA1 (P<0.001; Figure 5c), as well as surface expression of GluA2 (P=0.037; figure not shown).
However, inhibition of the clathrin-dependent pathway by CPZ abolished the endocytosis of MIF-TRITC and arrested MIF-TRITC at the cell surface (Fig. 1B).
When we introduced an alanine to this position, it completely abolished the MAVS activity, suggesting that the charged D53 may enforce the hydrophobic interaction above the aqueous surface.
It abolished the commission.
It abolished the death penalty.
You've abolished the "cohort".
Glyburide abolished the inhibitory effect of iptakalim.
Google has abolished the traditional blind date.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com