The phrase "abolished the function of" is correct and usable in written English.
It can be used in contexts where a specific role, duty, or capability has been officially removed or rendered ineffective.
Example: "The new policy abolished the function of the previous committee, streamlining decision-making processes."
Alternatives: "eliminated the role of" or "terminated the function of".
Deletion of genomic B108 by CRISPR/Cas9 in vivo using electroporation abolished the function of Blimp1.
In addition, frameshift mutations in the essential cag PAI genes cagX and cagY in J166output strains isolated after 2 and 6 months apparently abolished the function of the cag PAI type IV secretion system that delivers the immunogenic effector protein CagA into the epithelial cells, suggesting selection against a functional cag PAI (Supplementary Fig. 2 and Supplementary Tables 14 19).
Finally, we have shown that mutation of amino acids L33A and L34A almost completely abolished the function of NES, suggesting the important roles of leucine in NES function (Figure 4C).
Substitution of the C35 residue abolished the function of the transporter, while the C30S and C64S substitutions only partially affected PtdMTP1 function.
Interestingly, 10-amino-acid deletion from the N-terminus of MLKL abolished the function of MLKL in TNF-induced cell death, demonstrating the importance of the N-terminal portion in the function of MLKL.
The D276 mutations abolished the function of GSDMD as reconstituted GSDMD expression with D276N or D276A mutant of GSDMD cannot restore the induction of pyroptosis and IL-1β secretion by LPS plus nigericin, demonstrating that cleavage of GSDMD by caspase-1 is a critical step in inflammasome signaling.
It is also suggested that our construction strategy of OmpC-MT fusion protein for membrane targeting did not abolish the function of OmpC, as the dual functional OmpC-MT fusion protein could not only regulate compatible solutes but also reduce radicals to elevate the host's n-butanol tolerance.
From results, we suggested that our construction strategy of OmpC-MT fusion protein for membrane targeting did not abolish the function of OmpC, as the dual functional OmpC-MT fusion protein could not only regulate compatible solutes and glucose but also reduce radicals to elevate the host's toxins' tolerances.
Moreover, loss of the PBZ motif of APLF abolishes the function of APLF in DNA damage repair.
The neomycin gene is therefore inserted into one exon or it may replace some of the coding sequences, which have to be deleted to abolish the function of the gene to be targeted.
