Sentence examples for abolished activities from inspiring English sources

In these, two prototypic TKI, gefitinib and erlotinib, demonstrated the expected reduced or abolished activities.

Functionalized picolinamides 19g– 19o were uniformly active at both mGlu1 species, yet abolished activity at mGlu4 (EC50s >10 μM).

Deletion of the HMG-like sites abolished activity whereas ectopic SOX9 expression could even activate the enhancers in non-chondrocyte cells [ 18, 20].

Replacement of the ribose ring system with cyclopentyl or rigid bicyclo[3.1.0]hexane groups abolished activity.

Small meta-substituents were tolerated but groups in the ortho-positions reduced or abolished activity.

Replacement of the 5-nitroso substituent with ketone, oxime and semicarbazone groups essentially abolished activity.

Clearly organic component(s) of the extracts are responsible for the elicitor activity, since ashing the extract completely abolished activity.

The β-glucoside was twofold less potent than the native α-isomer, but methylene replacement of the 1′′-oxygen abolished activity.

Mutations of Tyr134 and Met144 resulted in the largest overall increase in Km, whereas mutagenesis of residues Glu18, Glu145 and Asp168 completely abolished activity.

As for 4E-BP phosphorylation, G2019S increased autophosphorylation activity by about two-fold (Figure 1B) and D1994A abolished activity (data not shown).

Mutation of two amino-terminal hydrophobic residues (IV 252/253) also completely abolished activity, whereas the VI 277/279 mutation had a more minimal effect (lanes 6 and 15).