In silico modelling shows that the missense mutation is likely to prevent DNA binding and abolish transcription factor activity (Fig. 1D).
Zhang and coworkers [ 19] showed that mislocalizing PTEN to lipid rafts abolished growth factor signaling in the PI3K pathway.
Mutation of the internal dinucleotide within the E-box elements from 5′-CACGTG-3′ to 5′-CAAATG-3′ (Fig 1A) abolishes nuclear factor binding(Chen et al, 2012).
The use of passive immunoneutralization technique in order to abolish an endogenous factor by using a specific antisera predates the discovery that pituitary hormone secretion is pulsatile in nature [ 28].
These SNPs, located in the promoter, are potentially involved in the Th1 immune response and in the Th2 regulation pathway since they were identified by in silico search to abolish these transcription factor recognition sites.
Early detection and adequate treatment can modify or even abolish the risk factors and thus prevent cardiovascular disease [ 5- 8].
These previous reports point to the idea that, apart from eIF4GI, HIV-1 PR may cleave an additional translation factor to abolish protein synthesis.
Butyrate significantly inhibited transcription of the CD44 gene and abolished epidermal growth factor-mediated up-regulation of the reporter gene luciferase subcloned upstream to the CD44 promoter (−1.1 kb) and transfected to HM7 cells.
If lifespan extension due to DR is dependent upon a single factor, removal of that factor will completely abolish the DR effect.
In addition, the suppression of α-SMA, PDGF-βR, proCol-1a1 by DMA were abolished while nuclear factor-erythroid 2-related factor 2 (Nrf2) silence in CML-treated HSCs.
