Sentence examples for abolish activity from inspiring English sources

Although such frameshift often abolish activity, the cloned system, including RM, S1 and S2 demonstrated MTase activity recognizing the palindromic site CY ANNNNNNN TRG.

However, removal of calcium does not completely abolish activity, indicating that calcium binding at these sites is not essential for activity.

Little is known about the impact of missense mutations on protein function, although substitutions in the FHA domain and the kinase domain have been shown to abolish activity [ 22, 26, 27].

The TGTGAGAGA element in POS9B was mutated to TCTGATCGA, and the resulting pKLP132 also did not abolish activity, as two of twelve transformants showed GUS staining in the ovules in an INO-like pattern.

Methylation at the N3 position (compound 9, Table 1) would be predicted to reduce but not abolish activity because, although the hydrogen bond interaction with Glu308 would be lost, the water mediated interaction with the hinge via N1 is maintained.

The majority of the remaining variants have lysine or glycine replacements (Additional file 15: Table S4), which were not tested by site-directed mutagenesis [ 54], but likely abolish activity.

Functionalized picolinamides 19g– 19o were uniformly active at both mGlu1 species, yet abolished activity at mGlu4 (EC50s >10 μM).

Deletion of the HMG-like sites abolished activity whereas ectopic SOX9 expression could even activate the enhancers in non-chondrocyte cells [ 18, 20].

Replacement of the ribose ring system with cyclopentyl or rigid bicyclo[3.1.0]hexane groups abolished activity.

Small meta-substituents were tolerated but groups in the ortho-positions reduced or abolished activity.

Replacement of the 5-nitroso substituent with ketone, oxime and semicarbazone groups essentially abolished activity.