Sentence examples for abolish active from inspiring English sources
Although it does not appear that long-range movement of CB1R occurs via actin-based mechanisms as observed with D2, since depolymerizing microtubules does not completely abolish active transport and since opposing pharmacological treatments to disrupt or stabilize actin caused significant differences in trafficking parameters, some actin-based trafficking of CB1R may occur.
We find that PP2 treatment completely abolished active invadopodia in control (data not shown) and FAK-deficient B16F10 cells, thus establishing the essential role of Src in the control of matrix degradation.
Functionalized picolinamides 19g– 19o were uniformly active at both mGlu1 species, yet abolished activity at mGlu4 (EC50s >10 μM).
Ablation of menin almost abolished both active and repressive histone modifications and reduced expression of 5'Hoxa cluster genes, Hoxa5 to a10 in AT1 cells.
Control digests of plasmid DNA confirmed that the DNAse was active and could abolish the inflammasome activating activity of plasmid DNA (Fig. 5A).
Mutating the active site cysteine (C277S) was already frequently employed to abolish TG2 activity (Akimov et al. 2000; Akimov and Belkin 2001b; Balklava et al. 2002).
Importantly mutation of a residue (D628A) that coordinates manganese in the active site abolished phosphatase activity.
DOI: http://dx.doi.org/10.7554/eLife.11315.030 10.7554/eLiFigure15.031 Figure 7. DA mutations in Smc1 and Smc3 ATPase active sites abolish chromosome binding and ATPase activity.
Here, alkylation of His at the active site of PhTX-I markedly abolished enzymatic activity (<4% residual activity).
Replacement of the interacting partners with a pair of H-bond acceptors completely abolishes ribozyme activity, presumably through disruption of the active-site structure.
Two mutations in the upper lobe β-sheet (T125A and Q164H) and one mutation in the active site loop (S268I) abolish Rin4 binding, while another mutation in the active site pocket (D297A) enhances binding 10-fold [19].
