The phrase "abnormality we have" is correct and usable in written English.
It can be used when discussing a specific abnormality that is present or acknowledged in a particular context, such as in medical or psychological discussions.
Example: "The doctor explained the abnormality we have identified in the patient's test results, which requires further investigation."
Alternatives: "anomaly we possess" or "irregularity we observe".
"When the vast majority of disease has no correlation to any identifiable genetic abnormality, we have to stop thinking that everything is genetic".
Furthermore, since the linguistic characteristics of phenotypes depend, to some extent, on the anatomical localization of the abnormality, we have structured these test suites according to the 21 top-level HPO phenotypic abnormalities.
Because a principal objective of this investigation was to examine metabolic indexes to provide clinical guidance for selecting individuals at high risk for progression to disease despite the absence of clinical metabolic abnormality, we have determined the optimal cutoff point for the metabolic index with the largest ROC AUC, 2-h glucose at 114 mg/dl.
It is tempting to speculate that the abnormalities we have observed are due to the overexpression of the dual-specificity tyrosine- Y -phosphorylation regulatyrosine- Y -phosphorylation which is locatyrosine- Y -phosphorylationegion.
To understand the underlying mechanism for how LRP5 mutations lead to retinal vascular abnormalities, we have determined the retinal cell types that express LRP5 and investigated specific molecular and cellular functions that may be regulated by LRP5 signaling in the retina.
Taken together, these findings suggest that inhibition of CRMP2 phosphorylation at Thr514 in Gsk3-deleted neurons may partially explain the migration and dendritic orientation abnormalities we have observed.
Although we agree that the abnormalities we have elucidated in LCIS in this study do overlap with those described in vitro in epithelial-mesenchymal transition, LCIS remains a cytokeratin-positive, epithelial neoplasm.
Further studies are warranted to elucidate pathophysiological mechanisms and to determine to what extent the early abnormalities we have identified in DM contribute to the risk of cardiovascular disease.
In addition to these metabolic abnormalities, we have previously shown that women with GDM exhibit alterations on left ventricular diastolic relaxation parameters that do not normalize after delivery, an early stage of diabetic cardiomyopathy [ 19].
To determine if this enhanced TPO level is due to its receptor abnormalities, we have analysed 12 AMM patients for the presence of Mpl protein in their platelets and found it to be reduced in AMM relative to controls.
While rigorous behavioral studies will, in the future, determine whether loss of a lincRNA may result in specific behavioral abnormalities, we have made promising initial observations on two mutant strains.
