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However, the impression was that repetitive CMAPs were much more prominent after oxaliplatin than in any other circumstance, but it was not possible to devise any method for quantifying this abnormality to improve its specificity.
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All these neurophysiological abnormalities tended to improve after a detoxification program [120], which was coupled with an increased activity of the endocannabinoid system [121].
Inhibition of protein farnesyltransferase activity by FTIs has been shown to improve abnormalities in nuclear morphology in cells from subjects with HGPS and from animal models of the disease [15], [16], [17], [18], [19], [20], [32].
In patients with relevant metabolic abnormalities it is expected to improve both insulin sensitivity and the blood lipid profile and probably reduce the risk of long-term cardiovascular complications.
Some believe that finding more abnormalities is the right strategy to improve the nation's health, but how much it reduces death and disability is open to debate.
To the best of our knowledge, this is the first report that glycemic control failed to improve repolarization abnormalities.
This novel combination therapy may provide an additional treatment strategy to improve metabolic abnormalities in lifestyle-related diseases.
Therefore, it is unlikely that the failure of glycemic control to improve repolarization abnormalities is attributable to the medicines used for glycemic control in the present study.
It has also been used successfully to control uraemia in patients who have refused dialysis [ 97] and to improve the abnormalities in gut barrier function in uraemia [ 98].
Postoperative complications occur more frequently in the presence of poor tissue microvascular flow and oxygenation [ 3- 5], and dopexamine has been shown to improve these abnormalities [ 6].
In contrast to the failure of glycemic control to improve repolarization abnormalities in the present study, protective effects of BP and lipid control have been reported in patients with diabetes and/or hypertension [ 28, 38, 39].
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