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A major influence on the determination of whether an initially missed abnormality should have been identified arises in the form of hindsight bias, defined as the "tendency for people with knowledge of the actual outcome of an event to believe falsely that they would have predicted the outcome" [6].
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The trigger time was defined as the time of the first recorded physiological abnormality that should have triggered a call-out of the local RRS or, alternatively, the actual time of call-out if not related to a physiological abnormality (for example, nursing staff concerned about a patient).
In the case of translational studies designed, for example, to discover and develop therapies to exploit oncogenic abnormalities, the tumours should have the appropriate molecular genetic defect.
Patients with hypokalemia or hypophosphatemia should have electrolyte abnormalities corrected prior to initiation of nilotinib.
A further assumption is that diseases that share features of expression abnormality for the same tissue type should have partially shared etiology.
If a needle biopsy based upon palpable abnormalities or mammography/ultrasound is indicated, you should have a needle biopsy to rule out cancer.
Moderate cases should have all thermal and cardiorespiratory abnormalities corrected and can benefit from serotonin antagonists.
Any patient with MGUS should have a bone marrow biopsy and aspirate examination with karyotyping to detect chromosomal abnormalities consistent with multiple myeloma.
This should have negative effects in both control and contaminated areas, predicting increases in the frequency of abnormalities.
And yet, if someone has committed heinous crimes and is then found to have bad genes or a neurological abnormality, should we presume that biology compelled him?
If an abnormality is present, the broad type of abnormality should be defined.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com