Sentence examples for abnormality of mitochondrial from inspiring English sources
No major abnormality of mitochondrial DNA copy number was detected in muscle DNA from any of the patients with compound heterozygous SPG7 mutations (Table 1).
A growing body of evidence supports the hypothesis that the abnormality of mitochondrial biogenesis is tightly associated with neurodegenerative diseases, including PD. mtDNA depletion may occur in neurons in sporadic PD brains, which reflects an impairment of mitochondrial biogenesis.
Abnormalities of mitochondrial fusion and fission have been reported in several mitochondrial disorders [43,44].
Abnormalities of mitochondrial function are known to occur in the AD brains as well.
Indeed, reports are beginning to surface of severe congenital cardiomyopathies attributed to primary abnormalities of mitochondrial respiratory chain function (Dhar et al, 2013; Garcia-Diaz et al, 2013).
Lymphoblasts from HD patients bearing a heterozygous 48 polyglutamine repeat (48Q) display striking abnormalities of mitochondrial ultrastructure (Mormone et al, 2006).
130 Therefore, abnormalities of mitochondrial complex 2, attributable to SDH germline mutation or not, may be implicated in another oncogenic pathway than KIT/ PDGFRAs.
There are further possible explanations to link environmental effects such as diet and physical activity with abnormalities of mitochondrial oxidative proteins in patients with type 2 diabetes.
In patients with mitochondrial disease, mitochondrial function is vulnerable to damages due to deletions, mutations or replication abnormalities of mitochondrial DNA (mtDNA) resulting in energy depletion and increased susceptibility to apoptosis [ 4].
The mitochondrial theory of aging goes on to postulate that the accumulation of mtDNA mutations will lead to abnormalities of mitochondrial respiratory chain proteins, causing partial uncoupling of the respiratory chain.
By these mechanisms, in severe lead intoxication there is an accumulation of large amounts of delta-aminolevulinic acid (a compound with inherent neurotoxicity), and there are abnormalities of mitochondrial function in all cells of the body.
