The phrase "abnormality in human" is not correct as it is missing an article and should be "abnormality in humans" or "abnormality in a human." You can use it when discussing deviations from typical human characteristics or behaviors in a medical, psychological, or biological context.
Example: "The study focused on the abnormality in humans that affects cognitive function."
Alternatives: "human anomaly" or "deviation in humans".
A frequent abnormality in human infants is spina bifida, in which the spine fails to close over and a gap is left in the vertebral column.
Losses on chromosome 17q, the most common cytogenetic abnormality in human medulloblastoma, have been associated with classic or large-cell histology, while losses on 9q have been associated with desmoplastic tumors.
Thus, loss of regulation upstream of Mst1/2 is a common abnormality in human HCC and may account for Yap activation in these tumours.
Since mutation of the p53 gene is the most frequently-detected abnormality in human tumours, gene therapy specifically targeting tumour cells with mutated p53 has been performed.
Abnormalities of the p53 gene caused, by a wide range of cellular stresses including hypoxia are the most common molecular abnormality in human cancer, which were found in more than 50% of malignancies [ 55].
While extensive efforts have been devoted to study promoter DNA hypermethylation as a common epigenetic alteration in cancers (Jones and Baylin, 2007, Suzuki et al., 2002), global DNA hypomethylation is recognized as an epigenetic abnormality in human tumorigenesis as well (Feinberg and Vogelstein, 1987).
Scientists have pinpointed a genetic abnormality in humans -- one originally discovered in plants -- that increases susceptibility to Crohn's disease, a chronic inflammation that shreds the lining of the digestive tract.
Although it is widely accepted that filaggrin (FLG) deficiency contributes to an abnormal barrier function in ichthyosis vulgaris and atopic dermatitis, the pathomechanism of how FLG deficiency provokes a barrier abnormality in humans is unknown.
Variations of SALL4 are associated with upper limb abnormality in humans (Kohlhase et al. 2002; Paradisi and Arias 2007).
Down syndrome (DS) is the most abundant chromosomal abnormality in humans, affecting between 1 800 and 1 1200 of the population.
Despite being the most common developmental cardiovascular abnormality in humans, the genetic cause(s) and molecular mechanisms underlying BAV and the associated aortopathy are not well understood.
