The higher is the score, the higher is the abnormality of development evident at or before 36 months.
Detection of cytological abnormalities by microscopic examination of Pap smears and subsequent treatment of women with high-grade cytological abnormalities avoids development of cancer [ 3].
Anything which encourages abnormalities of development and growth is likely to also affect development of the baby's brain.
In either case, abnormalities of development occur because of the unusual genetic signals transmitted by the chromosomes.
These abnormalities in development are often associated with PAH and alkylated PAH exposure.
RNF13 -/- mice display no overt physiological abnormalities during development, as previously described (Zhang et al., 2013b); in the present study, RNF13 -/- mice were used to assess the significance of RNF13 function in regulating skeletal muscle regeneration.
This form of cortical dysplasia is due most probably to neuronal migration abnormalities during development [7].
Genetic disruptions of BMPs have resulted in various skeletal and extraskeletal abnormalities during development [5], [22], [23].
GPR4 deficiency leads to partially penetrated vascular abnormalities during development and that this receptor functions in blood vessel pH sensing in an ex vivo aortic ring assay [10].
Finally, forced expressions of either MEF2C or PGC-1α are known to lead to mitochondrial ultrastructural abnormalities and development of cardiomyopathy[8], [22], [23].
