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They reported abnormalities that resembled apoptotic changes of the RPE.
Overexpression in mice of one of the genes in this interval, Ets2, led to skeletal abnormalities that resembled those in humans with DS (Sumarsono et al., 1996).
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The number of investigations in this area is rapidly growing in recent years with several hallmark studies verifying in murine cancer models that genetic perturbations (Dicer1 deletions, Wnt/β-catenin mutations, etc) in healthy BM-MSCs can be the sole orchestrating force for the onset of hematopoietic abnormalities that resemble leukemia [11,12,13].
Loss of neurons within the dorsal vagal motor nucleus and degenerative changes of the vagal nerve fibers have been noted.10, 89 Experimental lesions of the brainstem and vagus nerves in animal models (see below) can produce esophageal motility abnormalities that resemble achalasia.
Two reports have found that knockdown of ribosomal protein 19 (RPS19) in zebrafish results in dramatic loss of red blood cells as well as morphological abnormalities that resemble DBA (Danilova et al., 2008; Uechi et al., 2008).
Results The authors report that mice with combined depletion of DA and ACh demonstrate cognitive abnormalities that resemble PD dementia, such as diminished executive functions and impaired visual-spatial memory.
Loss of PS1 function was shown to inhibit normal migratory trajectories of neurons during neurodevelopment (Louvi et al. 2004), and deficiency of APP further reduces not only viability of postnatal mice but also produces cortical developmental abnormalities that resemble lissencephaly, a cortical condition in which no normal gyri are formed in the brain of humans (Herms et al. 2004).
Interestingly, Freeman et al. reported vascular abnormalities in Pten Δ 5/+ mice that resembled angiomatosis or hemangiomas, and the onset and spectrum of tumor formation were dependent on the genetic background (Freeman et al., 2006).
Joseph favoured vessels that resembled basketwork.
The skull's shape had features that resembled fish, and others that resembled later land animals.
And something that resembled a smoking apparatus.
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