However, recent studies show that iPSC lines carry genetic abnormalities, suggesting that reprogramming may be mutagenic.
Embryos homozygous for a mutation of Pax-6 (Small eye; Sey) had abnormalities suggesting defective migration of late-born cortical precursors.
Mutant zebrafish that express a truncated VEGF-C lacking the C-terminal domain (vegfc um18) have lymphatic abnormalities, suggesting that the C-terminal domain has an important role during development of the lymphatic vasculature5.
Such an increase likely results from renal impairment associated with volume regulation abnormalities, suggesting a potential role for ADM in volume regulation after liver transplantation.
Pretransplant chest radiograph abnormalities suggesting mycobacterial infections should be aggressively evaluated in these immunocompromised hosts.
Moreover, greater excitability levels are found in patients with chromatic perception abnormalities suggesting a potential pathophysiological relationship between peripheral and central visual dysfunction in these patients.
Both gain-of- and loss-of-function mutations of the MECP2 gene lead to neurodevelopment disorders with dendritic spine morphological abnormalities, suggesting the proper level of functional MeCP2 is critical for neural development (Jiang et al., 2013; Xu et al., 2014).
Interestingly, these quantitative brain abnormalities included the temporal lobes, the region in which we have found abnormalities, suggesting a possible link between quantitative and qualitative approaches.
Comparison with available data on SD birds showed similar abnormalities, suggesting that social segregation from adults may induce the same effects on perceptual development as a physical separation.
Similarly, in vitro experiments have shown that CpG stimulation could readily induce non-clonal cytogenetic abnormalities suggesting newly acquired genomic instabilities (Wu et al., submitted for publication).
