None of the families shows abnormalities concerning number of members or presence/absence of essential small GTPases.
For instance, EGFR-targeted inhibitors could be coupled with inhibitors of KRAS, MET, PI3K, IKK, HER2, HER3, or even with inhibitors of HER2/HER3 dimerization, to anticipate resistance mediated by genetic abnormalities in members of these downstream or parallel pathways.
Once a diagnosis for MODY is made, other family members, both diabetic and nondiabetic, should be screened for the family-specific mutation and possible abnormalities of carbohydrate metabolism.
It can be activated by any member of hospital staff according to pre-determined criteria that are based primarily on abnormalities of vital signs and clinical status.
The film portrayed the abnormalities of normal family life.
This method can also be used to detect abnormalities in any member of the parent child trio using inheritance-based expectations of genotype and BAF values (Table 2).
RECQL4 is one of five members of the human RecQ helicase family, and is implicated in three syndromes displaying accelerating aging, developmental abnormalities and a predisposition to cancer.
Previous studies seeking cellular abnormalities in the family members of lupus patients focused on a limited number of phenotypes, including examination of antibody-secreting cells, NK cells, and CD56+ T cells, and had significantly smaller sample sizes.
The sheer abnormality of his actions themselves suggested some element of mental disorder," said Lord Judge.
At the other extreme, red-top papers emphasise the abnormality of a murderer.
