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Abnormalities in the expression of EGFR play a critical role in the development of different types of cancer.
The present study was designed to investigate the abnormalities in the expression of apoptosis-associated proteins that lead to the progression of breast cancer.
Similarly, psychiatric patients can display abnormalities in the expression of cytokines and neurotrophic factors.
We found no abnormalities in the expression of E-cadherin, a protein known to be involved in cell-cell adhesion (data not shown) [17].
We have now identified a defective lamin A-Rb signaling network in cells from subjects with HGPS and demonstrated that treatment of cells with an FTI reverses abnormalities in the expression of genes encoding proteins in this network.
The disruption of physiological rhythms in these animals was related to abnormalities in the expression of clock genes and those involved in energy metabolism, suggesting PPARGC1A to be a component which integrates the circadian clock and energy metabolism.
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Accumulating evidence shows that the progression of tumorigenesis frequently involves abnormalities in the expressions of cyclins and other cell-cycle related genes [ 1- 3].
These chimera embryos, however, demonstrated severe abnormalities in the expression patterns of epithelia markers, and they died shortly after birth because of skin defects.
Moreover, abnormalities were found in the expression of the regulator of RGS4 in schizophrenia using cDNA microarrays (Mirnics et al, 2001).
Genetic alterations and a chaotic tumor microenvironment, such as hypoxia, acidosis, free radicals, and cytokines, are clearly attributed to numerous abnormalities in the expression and signaling of VEGF and its receptors.
This Treg defect is linked with abnormalities in the expression and function of CTLA-4.
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