The phrase "abnormalities in a substantial" is not complete and lacks clarity in written English.
It could be used in contexts discussing significant or considerable abnormalities, but it needs to be part of a more complete thought or sentence.
Example: "The study revealed abnormalities in a substantial number of participants, indicating a need for further investigation."
Alternatives: "irregularities in a significant" or "anomalies in a considerable".
Moreover, contrast-enhanced CMR could detect the presence of LE, mainly localized to the LV, even in the absence of wall thinning or kinetic abnormalities in a substantial proportion of apparently "healthy" carriers.
However, the incorporation of home capillary blood glucose sampling provides evidence of glucose abnormalities in a substantial proportion of individuals, indicating that population-wide diabetes screening practices need to be improved.
Fourthly, the angiographical course of arterial disease, with frequent early progression and subsequent stabilization or improvement (Chabrier et al., 1998; Sébire, 2006), leaving residual arterial abnormality in a substantial proportion, suggests an inflammatory mechanism.
Hair abnormalities occur in a substantial proportion of human patients with mitochondrial disorders.
However, taken together, the current study and existing literature would strongly support the hypothesis that cellular immune abnormalities exist in a substantial subset of children with autism.
Due to the profound genetic heterogeneity, the knowledge about distinct cytogenetic alterations was mainly restricted to the most frequent abnormalities (−5/5q−, −7/7q−, +8, 20q−, and −Y), although, in MDS, rare chromosome abnormalities are present in a substantial portion of patients.
Amyloid deposition and/or white matter abnormalities are present in a substantial proportion of clinically normal older adults.
Unfortunately, these abnormalities formed a substantial part of all new and unexpected abnormalities in our analysis (1.0% and 1.2% of all daily routine CXRs showed these two findings).
Somatic mutations and regulation abnormalities in a tumor cell cause substantial gene expression changes [ 2].
It is known that high-resolution CT (HRCT) is more sensitive than chest radiographs in detecting structural lung abnormalities in CF and early abnormalities can be seen on HRCT in a substantial number of patients with normal radiographs [ 16– 20].
In a substantial portion of patients with complex abnormalities, an exposition to therapeutically applied mutagens, like anthracyclines, topoisomerase II inhibitors, alkylating agents, and/or irradiation, can be traced in the medical history [ 40].
