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Vinik presented a study with photomicrographs of skin biopsy specimens showing reduction in intraepidermal nerve fibers in the proximal leg in association with metabolic syndrome as well as diabetes, with evidence that such abnormalities improve with lifestyle intervention (79).
Epidemiological studies have shown that SDB is a risk factor for prevalent and incident diabetes, and recent clinical trials indicate that metabolic abnormalities improve with treatment of SDB (19, 20).
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There are an insufficient number of prospective randomized trials to clearly demonstrate that surgical removal of all abnormalities improves IVF-ET outcome.
Her cardiac abnormalities improved.
After supportive therapy, the laboratory abnormalities improved.
All abnormalities improved on repeat EEG testing.
Symptoms and pulmonary function abnormalities improved with cessation of exposure and, in one worker, recurred with repeat exposure.
Mentation and gastrointestinal abnormalities improved after starting treatment with fluconazole, acyclovir, and symptomatic medications for erosive esophagitis.
Although radiographic abnormalities improved over time, abnormalities on chest radiographs, as reflected in median scores, did not decline from 2.0 at enrollment.
In the non-responders some abnormalities improved (mucous plugging, centrilobular abnormalities, airway wall thickening and ground glass opacities), but bronchial dilatation, consolidation and air trapping worsened.
Compared with the control group, the AT-MSC-treated group had a higher survival rate, decreased histological and serological abnormalities, improved immunological function, and a decreased incidence of proteinuria.
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