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A genomic deletion involving an intervening transcriptional termination signal resulted in abnormal spreading of an antisense transcript into the human α-globin gene and resulted in transcriptional silencing associated with DNA hypermethylation [26].
Similarly, knock-down of PAR-1 in the early embryo leads to abnormal spreading of AJs in the apicolateral region, but in embryonic epithelia PAR-1 is enriched in the apicolateral region versus the basolateral domain [59].
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Now, temperature maps indicate that the water has remained hot for longer than in the 2005 episode and the abnormal warmth spreads over a much broader area (see images).
These could act as seeds from which abnormal methylation spreads to the neighboring sequence.
In addition, the abnormal KO spreads exhibited far higher levels and more severe types of chromosomal aberrations than did the WTs.
Cancer is a genetic disorder that has always been a major threat all over the world and has been characterized by proliferation of abnormal cells and exhibiting an increasing mortality rate globally and being characterized by rapid formation of abnormal cells and spreading through metastasis to different organs [29, 30].
Analysis of cultured mesoderm explants and mouse embryonic fibroblasts from null mutants shows that the mesoderm migration defect is correlated with decreased cell spreading, abnormal focal adhesions, changes in the organization of the actin cytoskeleton, and decreased velocity of cell migration.
This abnormal architecture of the actin cytoskeleton is usually found in the early stages of abnormal non-polar cell spreading.
Cancer is a class of diseases involving uncontrolled abnormal cell growth and spreading [ 1].
The distribution and spreading of abnormal tau pathology in AD are temporally and topologically stereotypical, and correlate with clinical phenotype [ 1].
Ductal carcinoma in situ (DCIS): this condition is noninvasive and the abnormal cells are found in lining of the breast duct, but the spreading of the abnormal cells is not outside the tissues of breast.
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CEO of Professional Science Editing for Scientists @ prosciediting.com