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The score awards 0 (normal) to 4 (most abnormal) points for each organ system.
The criterion of abnormal points for FDT was defined by the presence of at least 5 points lower than P < 5%, 2 points lower than P < 2%, or 1 point lower than P < 1% on pattern deviation plot.
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For all 8 arcuate visual fields, the RGC + IPL and RNFL probability maps showed arcuate damage in the same region in which the visual field contained abnormal points.
As shown in Table 2, different assays for BNP or NT-proBNP measurements were used throughout the studies, with different cutoff points for abnormal levels.
The diagnostic criteria selected by Dangman et al. [ 2002] were designed to avoid the need for invasive biopsies, and were based on scoring points for; symptoms; crackles; abnormal pulmonary physiology; raised inflammatory markers; and abnormal radiology (on CXR, CT, or gallium scan).
To define cutoff points for high levels (abnormal laboratory values) of ESR and ALP, the gender-specific cutoff values from a priori study were referred to: ESR males >22 mm per hour, females >29 mm per hour (Magera et al, 2008); the cutoff point for ALP was >115U l−1 for both sexes (Motzer et al, 1999).
They consider natural proteins mere starting points for drug development, reasoning that a drug, which is treating an abnormal situation (ie, a disease), may thus need to produce an abnormal effect.
Furthermore, the 60% of predicted value cutoff-point for "abnormal" FENO was sensitive in discriminating reactors from non-reactors.
There is no clear cut-off point for abnormal oxygen saturation, but SpO2 ≤ 95% is used in most adult studies.
We used 60% of the predicted values of Olin and colleagues[ 17] as a cutoff-point for "abnormal" FENO for three reasons.
Using a less than optimal cutoff-point for "abnormal" FENO, we showed that high FENO values are associated with AHR while low FENO values tended to be associated with normal airway responsiveness.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com