The phrase "abnormal modification" is correct and usable in written English.
It can be used in contexts where you are discussing changes or alterations that deviate from the norm or standard practices.
Example: "The study revealed an abnormal modification in the behavior of the subjects after the treatment was administered."
Alternatives: "unusual alteration" or "irregular change".
Prause, J. et al. Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis.
Abnormal modification, including glycation, induces neuronal proteins to misfold and form amyloid fibrils in a stepwise process from prefibrils to fibrils [19].
Innate immune responses were triggered passively after AbSV attack, in virtue of abnormal modification of innate immune macromolecules caused by AbSV infection.
This same sequence has similarity to 136IVLQDIGGKP145 from the tail fiber domain of Enterobacteria phage T4, suggesting that abnormal modification of ferritin subunit also appeared in the infected abalone.
We recently described altered localization, abnormal modification and loss of function of SigR1 in sporadic ALS.
Recently, we reported altered localization and abnormal modification of SigR1 in sporadic ALS and showed that loss of SigR1 function leads to deformities in ER structure, formation of ER-derived autophagic vacuoles and induction of ER stress.
More research is needed to elucidate abnormal modifications such as glycation which play an important role in the aggregation and toxicity of α-Syn [6].
This skill is acquired through a myriad of abnormal modifications of growth factor signalling cascades and expression of their messengers and effectors.
We then sought to correlate retinal phenotypes with abnormal modifications of tau as assessed by phosphorylation at AD-relevant epitopes known to be preferentially phosphorylated by GSK-3β (29).
The most studied histone modifications are histone acetylation/deacetylation, and more recently methylation/demethylation. In breast cancer, abnormal histone modification in combination with DNA hypermethylation is frequently associated with epigenetic silencing of tumor suppressor genes and genomic instability [ 2, 3].
ER stress causes a decrease in SEAP activity not via transcriptional suppression but via abnormal posttranslational modification, accelerated degradation, and reduced secretion of SEAP protein.
