However, compared with wild-type mice and single EphB mutants, histological evaluation of the medial cornu ammonis area 3 (CA3) in the hippocampus of Ephb1 Ephb2 compound null mice revealed abnormally broader localization, and thus abnormal migration of pyramidal neurons in this region but not in CA1 (boxed area, Figure 7A).
All abnormally migrating fragments were sequenced and results showed that all abnormal migration patterns could be attributed to previously described polymorphisms (Table 1).
RNA interference of Marlin-1 in vivo results in abnormal migration of newborn pyramidal neurons during the formation of the cortex.
Since many proteins containing intrinsically disordered regions have similar abnormal migration on SDS-PAGE gels, we hypothesized that Atg31 may have characteristics of an intrinsically disordered protein (IDP).
Abnormal migration of embryonic cells during fetal development may affect the final structure and connectivity of the brain, resulting in alterations in the neural circuits that control thought and behavior.
C-kit proto-oncogene activation results in mastocytes accumulation and abnormal migration and activation in various tissues[4], [5].
Beside the compromised oxidase activity, neutrophils from Hv1−/− mice also displayed abnormal migration and intracellular Ca2+ turnover [14].
To investigate if these phenomena are caused by abnormal migration due to the absence of LRP1, we performed two different kinds of in vitro migration assays.
We determined that the abnormal electrophoretic masses of the TRP47 were associated with the highly acidic TR domain, suggesting that the abnormal migration is due to acidic nature of the TRs within these ehrlichial TRPs [9], [44].
Additionally, during embryonic development, knockdown of the puf-A gene led to a reduction in the number of PGCs and their abnormal migration, suggesting that Puf-A is involved in the maintenance and migration of these primitive germ cells.
In MAM treated ferrets, disruption of radial glia is associated with abnormal migration; neurons are scattered in all cortical layers compared to normal ferrets where neurons accumulate in an inside-out pattern [21].
