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Unusual traces or insufficient yield correspond to either abnormal input RNA, or amplification failure.
Effectively, abnormal input may result in 'noisy' left anterolateral STC activity that disrupts functional connectivity with right anterolateral STC.
It is believed that dizziness can also be caused by dysfunction of the deep muscular proprioceptors in the upper cervical spine leading to abnormal input to the vestibular nuclei [ 19].
As there is some evidence to suggest that auditory processing is affected at the level of brainstem as a consequence of OM, it can be assumed that auditory cortex receives abnormal input from the brainstem which, in turn, results in abnormal auditory processing at the cortical level also.
In other words, knowledge from basic research should be combined with clinical, audiological, psychoacoustical, electrophysiological, and imaging studies in humans to characterize the lesion at the level of the auditory periphery and the changes induced in auditory brain areas by the abnormal input from lower auditory centers.
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No differences were identified in gross retinal anatomy (data not shown) or light-driven pupil constriction in Bdr mice suggesting that abnormal inputs from the eye are not the source of the circadian phenotype.
Thus abnormal MDT input to the pyramidal neurons in the mPFC may result in the lower spine density observed in GluN2C KO.
Abnormal cerebellar input to VIM is presumed to be a major contributor to tremor symptoms, which is alleviated by DBS.
This may be due to abnormal sensory input and/or altered descending inhibition from the supraspinal dopaminergic system.
The sIPSC/sEPSC ratio was significantly higher in Dlx-CKO cells indicating that these cells receive abnormal synaptic input.
Taken together, these results suggest that deficits in locomotor activity of Six3-Cre Lhx1lox/lox mice were not a result of abnormal retinal input to the SCN.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com