Exact(32)
All five patients with NICCD had infant hepatitis syndrome at diagnosis, presenting with jaundice and abnormal hepatic function tests, though all developed well with normal hepatic function tests after treatment.
Except for the presence of abnormal hepatic function, recombinant leukocyte α interferon was well tolerated after marrow transplantation.
It is also unclear whether abnormal hepatic function is related to pharmacokinetic exposure to buparlisib.
Clearance is affected in patients with abnormal hepatic function but remains unaltered in elderly patients [ 6].
Incidences of abnormal hepatic function will be monitored in Phase II/III trials.
Four pazopanib patients (1%) had fatal adverse events, including ischaemic stroke, abnormal hepatic function, rectal haemorrhage and peritonitis/bowel perforation.
Similar(28)
In addition, primary abnormal hepatic mitochondrial function could lead to steatosis, because patients with type 2 diabetes have reduced hepatocellular ATP levels that correlate with hepatic insulin sensitivity and HCL (22).
Patients with a cardiovascular disease, blood pressure > 160/100 mmHg, previous or present abnormal hepatic or renal function, antidiabetic medication, anaemia, or oral corticosteroid treatment were excluded.
Exclusion criteria include age < 18 years, fasting triglycerides > 16.5 mmol/L, recent history of myocardial infarction, liver, kidney, pancreas, or gall bladder disease, history of malabsorption of nutrients, current use of insulin, abnormal renal or hepatic function, and pregnancy or nursing in women.
Sixty-four subjects with advanced malignancies including pancreatic, hepatocellular, colorectal as well as other epithelial malignancies and either abnormal hepatic or renal function were treated on a phase I and pharmacokinetic study of weekly 24-hour intravenous infusions of 5-FU and leucovorin.
Six patients had an injection-site reaction (erythema, swelling, warmth, all in the MTX group) and three had a hepatic event (two in the MTX group, hepatic function abnormal and blood alkaline phosphatase increased; one in the non-MTX group, hepatic function abnormal).
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