Exact(6)
Abnormal display of PfEMP-1 and knobs on the surface of CB RBCs correlated with these findings and is reminiscent of that on HbC and HbS RBCs [10], [11].
Abnormal display of the parasite's cytoadherence antigen P. falciparum erythrocyte membrane protein-1 (PfEMP-1) on CB RBCs accounts for these findings and is reminiscent of that on HbC and HbS RBCs.
Abnormal display of the parasite's cytoadherence antigen P. falciparum erythrocyte membrane protein-1 (PfEMP-1) on HbF RBCs correlates with these findings and is similar to that on HbC and HbS RBCs [10], [11].
Recently, an abnormal display of PfEMP1, an antigen involved in malaria pathogenesis, was reported [7], [8] on HbAC and HbCC infected erythrocytes that showed reduced cytoadhesion and impaired rosetting in vitro.
A recently proposed mechanism of protection for haemoglobin C (HbC; β6Glu→Lys) links an abnormal display of PfEMP1, an antigen involved in malaria pathogenesis, on the surface of HbC infected erythrocytes together with the observation of reduced cytoadhesion of parasitized erythrocytes and impaired rosetting in vitro.
Previous studies have noted the abnormal display of PfEMP1 on the surface of infected erythrocytes from HbAS individuals that correlates with poor endothelial binding properties of such IE, perhaps providing a mechanical basis for the malaria-protective effect of HbAS [ 31, 32].
Similar(54)
The histology of the Wwox KO mice spleens was very abnormal displaying signs of spleen atrophy.
A similar picture of abnormal surface display of PfEMP1 has also been shown for HbAC and HbCC (Fairhurst et al, 2005), which also provides protection against malaria in both heterozygous and homozygous states (Modiano et al, 2001).
Results showed that the reported abnormal cell-surface display of PfEMP1 on HbC infected erythrocytes observed in vitro is not associated to lower anti- PfEMP1 response in vivo.
Results showed that the reported abnormal cell-surface display of PfEMP1 on HbC infected erythrocytes observed in vitro is not associated to lower anti- PfEMP1 humoral response in vivo.
ClinicalTrials.gov: NCT00246194 Schizophrenia is a chronic debilitating mental illness with a lifetime prevalence of 1% [ 1], characterized by perturbations of cognition and behavior and by abnormal or limited display of emotion.
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