Sentence examples for abnormal deficiencies from inspiring English sources

Because over 70 disease-linked GRN mutations cause abnormal deficiencies in the production of PGRN, a protein that plays a crucial role in embryogenesis, cell growth and survival, wound repair and inflammation, researchers now aim to design therapies that would increase PGRN levels in affected individuals, thereby alleviating the symptoms associated with disease.

If this process also occurs in the human CNS, reduced extracellular cystatin C concentration could result in reduced uptake and abnormal deficiencies in intracellular cystatin C activity.

Preneoplastic lesions in the mouse liver are indicated by an abnormal deficiency in glucose-6-phosphatase (14).

Abnormal signaling, deficiency of, or resistance to these hormones have been shown to have deleterious effects.

Other abnormal hemoglobins, G6PD deficiency and pyruvate kinase deficiency also confer some degree of resistance against falciparum malaria (reviewed by Allison 2009).

The etiology of anemia of critical illness is multifactorial; it often results from a combination of primary losses, abnormal coagulation, nutritional deficiencies, depressed bone marrow production, and phlebotomy.

The abnormal accumulation or deficiency of trace elements may theoretically impair the formation of bone and contribute to osteoporosis.

The adaptability of the learning scheme is tested also for the abnormal case of deficiency in one of the rear-legs.

Proposed mechanisms include platelet storage pool deficiency, abnormal platelet metabolism, endothelial cell changes, increased cyclic adenosine monophosphate (cAMP), abnormal platelet binding to von Willebrand factor (vWF), effects of anemia, and fibrinogen impairment [ 4– 9].

There is strong evidence that abnormal expression and quantitative deficiencies of essential molecules such as extracellular matrix (ECM) proteins, transcription factors, and ribosomal proteins can seriously impair embryonic development.

Bleeding tendency may not always be related to absolute platelet counts but may be influenced by coagulation factor deficiencies or abnormal platelet function.