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In a study which one expert said challenged the idea that "casual" marijuana use is largely harmless, doctors found that young adults who used the drug only recreationally had "abnormal alterations" to the nucleus accumbens and the amygdala.
Molecular imaging allows the monitoring of abnormal alterations of c-MET in real time and in vivo.
The present modeling approach can be utilized to explore effects of abnormal alterations in the isostatic flow on the microarchitecture of the calcaneal trabeculae, as well as for better understanding of the mechanisms of calcaneal fractures.
Since these processes control cell growth and differentiation, abnormal alterations of these signaling pathways result in malignancies.
In the present study we found that in Per1 mutant mice the grooming behavior and anti-nociceptive effect induced by immobilization stress showed abnormal alterations compared to wild type mice and Per2 mutant mice.
Here, we refer to epimutations as heritable, abnormal alterations in the state of chromosomal regions.
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c-MET-targeted molecular imaging makes it possible to visualize the abnormal alteration of c-MET expression in vivo and in real time, with the potential applications such as patient screening for c-MET-targeted therapeutics, monitoring therapeutic effects, evaluating prognosis, and analysis for resistance mechanism.
The idea that abnormal alteration (disruption or enhancement) of specific protein interactions can lead to human diseases complements canonical gene loss/perturbation models and provides new clues on mechanisms underlying human diseases [ 67].
Active anticancer components are known to exhibit a consistent antitumor effect by blocking abnormal expression alterations of multiple signaling proteins, such as VEGF, p53, JAK-STAT, and CDC14A [454 55] 55].
Abnormal genetic alterations in palmdelphin (PALMD) are observed in the malignant tumors.
Abnormal methylation alterations may have serious consequences for placental growth and functioning and, in turn, for developing infants' health.
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