This mutation results in haploinsufficiency of RUNX1, as the mutant protein has lost its capacity to bind DNA and to transactivate the expression of the target genes [ 9].
IL-6 appears to be able to transactivate the androgen receptor in the absence of androgens at the N-terminal domain as well as increase the mRNA for the androgen receptor.
Since SlEOT1, SlMYC1 and SlWRKY73 were shown in separate experiments to be able to transactivate the SlTPS5 promoter, we investigated what effect a combination of these transcription factors would have on the transactivation of this promoter.
Of importance, PARs seem also to be able to transactivate the sphingosine-1-phosphate receptor 1 (S1PR1) by a similar mechanism involving rapid release of its agonist, sphingosine-1-phosphate (S1P).
Interestingly, despite reduced FOXC1 protein levels, FOXC1 was able to transactivate the luciferase reporter gene after exposure to a 'high dose' of H2O2.
Therefore, at least at early time points, BPA is able to transactivate the embryonic ERs and resembles DES rather than EP in its kinetics of luciferase activation.
Moreover, FUS-DDIT3 is able to transactivate the eIF4E promoter suggesting that FUS-DDIT3 is able to interfere with the translational initiation machinery and disrupt the normal adipocyte differentiation program of adipocyte progenitor cells in liposarcomas.
NUP98-HOXA9/N51S did not transactivate the KBTBD10 promoter (Fig. 3A); but surprisingly, it was able to transactivate the PLN promoter to the same extent as NUP98-HOXA9 (Fig. 3B).
FOXC1 was able to transactivate the luciferase reporter gene under 'no H2O2' conditions.
A previous study showed that overexpression of SND2 produced a fibre cell-specific increase in secondary cell wall thickness in Arabidopsis stems, and that the protein was able to transactivate the cellulose synthase8 (CesA8) promoter.
