Sentence examples for able to reconstitute a from inspiring English sources

It was also reported that a single cell, CD45−Ter119−CD31−Sca1lowCD24medCD49fhigh, marked with a LacZ transgene, was able to reconstitute a complete mammary gland in vivo.

Humanized mice able to reconstitute a surrogate human immune system (HIS) can be used for studies on human immunology and may provide a predictive preclinical model for human vaccines prior to clinical trials.

With this approach, we were able to reconstitute a time course of mRNA changes related to the cell cycle and observed a sharp peak at an unexpected early time point, namely P9.5, during which a large cluster of genes related to the cell cycle was upregulated.

However, the Y2H system is prone to autoactivation artifacts, in which a protein expressed from a single vector, rather than as protein-protein dimer from complementary bait and prey vectors, is able to reconstitute a functional transcription factor to permit growth of the yeast.

Although preliminary, Wilson's data suggest that aHSCs originate from dHSCs and, subsequently, are able to re-enter a state of dormancy: (i) nearly all the LRC-dHSCs enter the cell cycle (thus becoming non-LRC-aHSCs) after treatment with the chemotherapeutic 5′-fluorouracil (5-FU), and (ii) 5-FU-activated and BrdU-pulsed HSCs are able to reconstitute a steady state pool of LRC-dHSCs.

To demonstrate that a single cell contained within this population is able to reconstitute an entire mammary gland they used the Rosa-26 mouse carrying a LacZ transgene, which allows for tagging of donor cells.

The existence of a mammary stem cell has now clearly been demonstrated using cell surface markers (Lin− CD29hi CD24+) to enrich for a single basal/myoepithelial cell from the murine mammary gland that was able to reconstitute an entire functional gland using the same assay (Shackleton et al, 2006).

Accordingly, we were able to reconstitute an interaction between a recombinant segment encompassing the N-terminal region of CENP-I (residues 57 281, which was expressed in a soluble form in the absence of other stabilizing components) and the CENP-H/K complex, thus confirming that CENP-H/K binds the N-terminal region of CENP-I.

Two of these HSCs would be classified as a gamma subtype HSC, meaning that they are lymphoid biased and unlikely to possess durable self-renewal activity (i.e., not able to reconstitute in a secondary transplantation).

Furthermore, mDOR has been inserted in LUVs of defined compositions, but we were never able to reconstitute it in a high-affinity state to observe the binding of agonists, even though this GPCR was characterized as inserted into the lipid phase of these LUVs (data not shown).

Recent reports that a chemically synthesized compound is able to reconstitute [2Fe]-hydrogenases, harboring an especially elaborate and highly efficient metal cofactor, promise to pave the way for gaining much deeper insight into the function of even complex metal enzymes.