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Being able to predict this successfully would bring great benefit, because this would potentially spare many patients from acute and delayed drug-induced toxicities, and avoid the useless spending of public and private healthcare resources.
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Influence functions, measured both prior to and following damage, were able to predict this behaviour.
Interestingly, DRUGSURV is able to predict this outcome.
The signature with the most robust predictive ability was BRmet50, as it was able to predict prognosis successfully in 23 out of 31 breast cancer datasets (74%) [ 32].
PMID20813035Sig137 was able to predict prognosis successfully in 56% (five out of nine) of ER- datasets (Table 4) while BRmet50 and PMID18271932Sig33 were able to predict prognosis successfully in 11%.
MMF was reported to be able to predict successfully both the initial and final failures for all the 12 specified test cases (Kaddour and Hinton 2012).
An accurate and reliable QSAR model involving five descriptors that is able to predict successfully the HCV inhibitory potency against genotype 1 HCV polymerase is presented.
The model is able to predict successfully the effects of hole size and lay-up upon the compressive strength and has been incorporated into a user-friendly computer program.
ENCAPP was able to predict prognostic outcome successfully for both colon and ovarian cancer (median AUCs = 0.666 and 0.766 respectively; 95% CIs for AUC = 0.658-0.674 and 0.760-0.771 resPectively; P = 0.001 and 0.097 respectively; Additional file 1: Table S1) confirming that it works robustly across different cancers.
These valuations showed that the presented model is successfully able to predict both MFC and MEC performance.
The results indicated that all the proposed models are successfully able to predict the ERAC in close agreement with the experimental results.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com