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The use of sugar moiety in the structure of sulfonamide-based CA inhibitors (CAIs), has allowed the discovery of very potent CA IX inhibitors able to impair the growth of both primary tumors and metastases.
Since biochemical and molecular alterations of sperm cells are known to be associated with impaired sperm quality, our findings suggest that involuntary smoking is potentially able to impair fertility in subjects exposed early in life.
Voinnet set out to investigate the other part of the story--the virus's response--which led to his discovery of a large variety of viral proteins able to impair the plant's silencing mechanism.
Our experiments lead to three interesting results: (1) there is a significant advantage in using SIFT classification, (2) the classification-based attack is robust against different SIFT implementations, and (3) we are able to impair a state-of-the-art SIFT-based copy-move detector in realistic cases.
Also interesting is the observation that anelloviruses may be able to impair replication of other viruses.
Interestingly, GSK3 inhibition decreases HDAC6 activity [44], but also is able to impair axon formation [45].
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The fact that GluA1 deletion was able both to impair short-term spatial memory, and enhance long-term memory suggests that these forms of memory depend on separate psychological processes that can, under some circumstances, compete with one another.
As thiol antioxidants seem to be able to profoundly impair induced autophagy, we examined whether they could impair autophagy induced by mTOR inhibition and basal autophagy.
Therefore, also a mild increase in IAP is able to substantially impair local as well as systemic circulation and organ perfusion.
These results suggest that IKKβ-KM overexpression was not able to completely impair endogenous IKKβ function.
The commonest organism found, M. salivarium, is able to profoundly impair the functions of key immune cells and thus suggests that Mycoplasmataceae may contribute to VAP pathogenesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com