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It can be assumed that antithrombin is also able to exert specific anticoagulatory and anti-inflammatory effects in thrombocytes via analogous biochemical mechanisms because it is known that syndecan-4 is also expressed by thrombocytes and that antisyndecan-4 antibodies can influence thrombocyte aggregation [ 71].
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As expected, after 10 µM PD98059 and LY294002 treatments, there was a reduction in the levels of p-ERK1/2 (p<0.01) and p-AKT (p<0.05), respectively (Figure 2D) confirming that both inhibitors were able to exert their specific effects.
However, mechanisms to exert specific control over cellular microenvironments remains a significant challenge.
This subclass of small chemotactic proteins is induced upon infection and is able to exert target-specific activities towards subsets of leukocytes, both myeloid and lymphoid (Groom and Luster, 2011).
Response rates to ligand specific signal-transduction vary, but imatinib is able to exert its anti-proliferative effect on all breast cancer cells in spite of PDGF BB stimulation.
LCRs are regions of genomic DNA which are able to exert long-range enhanced transcription of linked genes in a tissue-specific and copy-number dependant manner (i.e. proportionate to the number of gene copies in transgenic experiments).
No one was able to exert a grip.
The party should be able to exert some political power.
"They are able to exert a lot of pressure," Ms. Nestle said.
By accepting his offer, Labor may be able to exert a moderating influence.
It's all about being able to exert maximum effort and not overheat.
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